ABSTRACT
Objective: To study the DNA ploidy and DNA index (DI) in human benign and malignant bronchopulmonary change, and evaluate their value in diagnosis of benign and malignant bronchopulmonary diseases.Methods: The DNA ploidy and DI were analysed by image cytometry analysis (ICM) in 39 cases of bronchitis, 45 cases of squamous metaplasia, 45 cases of dysplasia,and 63 cases of carcinoma.Results: The mean DI for bronchitis and squamous metaplasia were 0.92 and 1.03 respectively, and dysplasia was 1.34,while the mean value for carcinoma was 1.72.Among the four groups,the difference was of evident statistical significance.Conclusion: The DNA content and DNA aneuploidy are with different percentage in benign and malignant bronchopulmonary pathological change.Quantitative analysis of the DNA ploidy and DI may be beneficial in diagnosis and differencial diagnosis of benign and malignant changes,which can provide objective data for clinical treatment and prognosis.